Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration

Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration.

The clinical evaluation of neural transplantation as a potential treatment for Huntington's disease (HD) was initiated in an attempt to replace lost neurons and improve patient outcomes. Two of 3 patients with HD reported here, who underwent neural transplantation containing striatal anlagen in the striatum a decade earlier, have demonstrated marginal and transient clinical benefits. Their brai...

Applying Bioinfomatics Strategies in Huntingtons Disease Research

Scrofuloderma-Like Lesions in a Patient with Hodgkin’s Disease

A 15-year-old boy presented with several months history of bilateral axillary lymph adenopathies which were ulcerated subsequently. He had received anti-tuberculosis therapy for more than six months based on suspicious diagnosis of scrofuloderma. Histopathologic examination confirmed the diagnosis of specific lesions of Hodgkin’s disease. These lesions were probably metastatic due to retrograde...

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

with heterotrimeric G proteins (Nishimoto et al., 1993), Alzheimer’s disease (AD) is the most common cause of and APPs can activate high conductance potassium progressive cognitive decline in the aged population. channels (Furukawa et al., 1996) and increase the activThe triad of amyloid plaques, neurofibrillary tangles, and ity of MAP kinase (Greenberg et al., 1994). However, the dementia that...

the genetic analysis of iranian patients with huntingtons disease

huntingtons disease (hd) is an autosomal dominant inherited disease characterized by involuntary movements, behavioral and personality changes, dementia and cognitive decline. although the mean age of onset is about 40 years, it varies from 5 to 79 years. therefore, at-risk individuals are never sure to have escaped the disease. hd is a member of the growing family of neurodegenerative disorder...